Talc users have been found to develop higher levels primary ovarian cancer including epithelial ovarian, or fallopian tube epithelial cancer with serous and mucinous borderline tumors, as well as invasive serous and endometrioid tumors. Primary peritoneal cancer is also related. Some of the cancers are “high grade” which means that the cancer spreads quickly. The risk appears to increase with more talc use (over ten years) and is also higher with African American users. Pathology studies have found microscopic talc particles in ovarian tissue. Special microscopes isolate these crystals which are also associated with an inflammatory response.